A new rule from the US National Institutes of Health (NIH) puts grant reviewers at risk. Beginning October 1, 2025, all new grant award notices will include language that allows the grant to be terminated if the agency determines that it no longer meets program goals or NIH priorities[7][1]. This measure is intended to prevent legal challenges in future cancellations of grants[1]. At the same time, NIH is implementing changes to the application review process, including eliminating the prior approval requirement for unsolicited applications over $500,000 in direct costs per budget period[1][2]. Requests for Intent (LOIs) are no longer required or accepted by the NIH[1][2]. Study Sections will reduce the percentage of applications discussed from the top 50% to the top 30-35%, with the middle third designated as "competitive but not discussed" and may be considered for priority funding[1]. These changes are intended to reduce the burden on controllers, enable one-day meetings and facilitate recruitment[1]. The unified funding strategy places less emphasis on review scores and more on NIH priorities, applicant career stage, or geographic location, effective January 2026[1][2].