The study compared traditional transfusion skills training with the BOPPPS blended learning model in 78 nursing trainees from October to December 2024. The control group (n=38) received standard training, the experimental group (n=40) received blended training based on Bridge-in, Objective, Pre-assessment, Participatory learning, Post-assessment and Summary. The experimental group achieved significantly higher scores in theoretical knowledge (68.91 ± 10.53 vs. 60.47 ± 17.03, p=0.010) and self-directed learning skills (94.84 ± 8.17, p<0.001). In operative transfusion skills, the difference was not significant (90.35 ± 2.02 vs. 89.71 ± 1.94, p=0.160). Interviews in the experimental group revealed themes: gaps in clinical practice, recommendations for model optimization, and benefits for competencies. The BOPPPS model improves theoretical knowledge and self-learning compared to traditional education.