Releasing male Aedes aegypti mosquitoes infected with Wolbachia pipientis (strain wAlbB) into the wild in Singapore reduced the risk of dengue infection in humans by more than 70%.[1] This bacterial infection causes sterility because the crossing of infected males with wild females results in non-viable eggs.[1][3] The study was conducted from epidemiological week 27 in 2018 to week 26 in 2022 in Yishun, Tampines, Bukit Batok and Choa Chu Kang.[1] Both spreading and targeted discharge strategies were used twice weekly in residential areas with high-rise buildings.[1] Intention-to-treat analyzes showed a protective efficacy of 47% after 3 months, 44% after 6 months, and 61% after 12 or more months of Wolbachia exposure.[3] When exposed for 12 months or more, the effectiveness was 49% to 77% in different years.[3] The ratio of virologically confirmed dengue cases was lower in the intervention areas.[3] The results confirm the potential of this technique to enhance dengue control in tropical cities.[1][3]