Luteal-phase stimulation does not compromise embryo euploidy or live birth outcomes compared to follicular-phase stimulation

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Source: Frontiers Medicine

Original: https://www.frontiersin.org/articles/10.3389/fmed.2026.1722250...

Published: 2026-02-11T00:00:00Z

A study compared luteal phase stimulation (LPS) with follicular phase stimulation (FPS) in IVF treatment and found that both methods achieve comparable results. The LPS group required a longer stimulation period (10.5 days vs. 9 days) and provided fewer retrieved eggs (6 vs. 9), but the embryo euploidy rate was not significantly different (33.9% with LPS vs. 30.8% with FPS). Clinical pregnancy, live birth, and pregnancy loss rates were comparable between groups—live birth rates were 41.2% for LPS and 46.2% for FPS. The researchers concluded that stimulation in the luteal phase does not compromise the chromosomal quality of embryos or reproductive outcomes. However, the lower egg yield with LPS could potentially affect cumulative pregnancy and live birth rates across multiple cycles. Nevertheless, the study suggests that LPS represents a clinically feasible and patient-friendly option due to the flexibility of treatment planning.