A study published in the New England Journal of Medicine tested a method to suppress dengue by releasing Wolbachia-infected Aedes aegypti mosquitoes in Yogyakarta, Indonesia. In areas with released mosquitoes, the incidence of dengue fell by 77% in people aged 3 to 45 years over a 27-month period. Hospitalizations due to dengue were reduced by 86% in treated areas. Efficacy was the same for all four dengue serotypes. The AWED study was a randomized controlled trial with 24 areas of one square kilometer each, where half received Wolbachia and half served as controls. The method is safe, well accepted by the community and results in a long-term reduction in the transmission of dengue, chikungunya, Zika and jaundice. The release took place every few weeks for nine months. The results confirm previous trials with similar incidence reductions.