The PRIMARY-AI paper proposes outcome-based standards to protect primary care in the era of artificial intelligence. These standards were published in Nature Medicine online on February 11, 2026 with DOI: 10.1038/s41591-025-04178-5. The goal is to ensure that AI systems in primary care meet the requirements for safety, quality and efficiency. The standards emphasize the need for human oversight and high-quality data for high-risk AI applications. They focus on protecting patients from the risks associated with AI in diagnosis and decision-making. These measures are intended to prevent negative impacts on primary health care.