The American Association for the Advancement of Science (AAAS), publisher of the journal Science, is holding its annual meeting in Phoenix, Arizona under the theme "Science at Scale." This confluence of academics, industry, government, business, medicine, law and ethics contrasts with the decline of science caused by the current US federal government. In the past year, there have been actions in Washington that have diverted science from breakthrough discoveries, including the cancellation of clinical trials of life-saving drugs and attempts to significantly cut basic research agency budgets. In 1982, the Panel on the Health of American Colleges was formed, and in 1986 it issued a report, "A Renewed Partnership," recommending doubling federal support for basic research and strengthening alliances between government, academia, and industry. The best science and innovation depend on scaling output, geographic reach and quality, which requires collaboration across disciplines, countries and cultures. Last month, Congress blocked an attempt to make deep cuts to federal science budgets through 2026. The scientific community must use this success to maximize the impact of public-serving institutions and collaborations.[1]