A comparative study of various advanced therapies for Crohn's disease found no significant differences in the risks of serious infections, blood clots, or major heart events.[1] These results suggest that concerns about the safety of these drugs should be reconsidered. The study focuses on the safety of drugs against Crohn's disease. The article further focuses on strengthening colorectal cancer (CRC) screening. The third part deals with the association of body mass index (BMI) with the risks of liver diseases. NSAIDs should be used with caution in patients with Crohn's disease due to the risk of disease exacerbation and serious gastrointestinal events.[1] The risk of bleeding, ulceration and perforation increases with higher NSAID dose.[1]