Interprofessional education (IPE) allows different disciplines to learn from each other and develop soft skills to improve patient care. The One Health concept emphasizes collaboration and interdisciplinary practice, recognizing the interconnectedness of human, animal and environmental health. Despite the common intersections, the integration of One Health into IPE is uneven and difficult to implement. The article synthesizes experiences from multi-university programs implementing health-focused IPE. Successful integration of One Health into IPE for professional students requires an extensive logistical plan, coordinated institutional support, and modeling of interdisciplinary collaboration by faculty. Integration must go beyond global concepts and include applications to future clinical practice.