A meta-analysis including 4,408,416 patients from 18 studies compared the outcomes of sepsis treatment in hospitals with different annual case volumes. Patients treated in high-volume hospitals had significantly lower in-hospital mortality compared to low-volume hospitals (OR = 0.90, 95% CI: 0.87–0.93). Similarly, mortality in intensive care units (OR = 0.93) and early mortality (OR = 0.81, 95% CI: 0.76–0.87) were lower in high volume hospitals. Patients in hospitals with a high volume of sepsis spent significantly less time in intensive care units (MD = −0.11 days). No significant difference in total length of hospital stay was observed between high- and low-volume hospitals. The study concluded that hospitals with high annual sepsis case volumes are associated with reduced mortality among sepsis patients.