Glanzmann thrombasthenia (GT) is a rare inherited bleeding disorder caused by a defect in the platelet integrin αIIbβ3, which is usually inherited in an autosomal recessive manner.[3][5] Although this disease typically presents with mucocutaneous bleeding, gastrointestinal bleeding is not uncommon and can be a potentially serious complication.[1] The study included six patients with type I GT (four women and two men) who had massive upper gastrointestinal bleeding of unknown cause.[1] Endoscopic findings were varied – from normal mucosa to visible vessels, polyps and arteriovenous malformations.[1] Treatment was tailored to the severity of each case and included a combination of recombinant activated factor VII (rFVIIa), tranexamic acid, endoscopic intervention, and supportive care.[1] All patients were successfully managed and bleeding control was achieved using antifibrinolytic agents and recombinant factor VIIa, which also reduces the risk of platelet alloimmunization.[1] The study suggests a possible association between certain variants of the ITGB3 gene and severe bleeding, pointing to the phenotypic variability of the disease.[1]