The article focuses on ensuring the functioning of the guidelines for the supervision of antibiotics in real health care conditions. Designing interventions that integrate seamlessly into the everyday environment is key to curbing the rise of antimicrobial resistance in resource-limited settings. A large pragmatic trial in China demonstrates that such an approach is possible. The study was published in Nature Medicine online on February 17, 2026 with DOI: 10.1038/s41591-026-04226-8. The main finding shows the success of applying these guidelines in practice. Interventions tailored to real conditions support effective antibiotic stewardship. This model can serve as an example for other environments with similar constraints.