Secondary Prevention after Ischemic Stroke

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Source: NEJM

Original: https://www.nejm.org/doi/full/10.1056/NEJMcp2415601?af=R&rss=currentIssue...

Published: 2026-02-18T10:00:05Z

Secondary prevention of ischemic stroke includes a complex of systemic, medicinal and surgical procedures, which, when used correctly, significantly improve the prognosis of patients[1][4]. Acetylsalicylic acid given in the first 48 hours after the event significantly reduces the risk of its recurrence, while the addition of dipyridamole or clopidogrel showed the same or slightly higher efficacy[1]. Control of arterial hypertension is crucial, as reduction of blood pressure reduces the relative risk of recurrent stroke by 28% or more[2]. Atrial fibrillation is the main cause of a cardioembolic ischemic event and without antithrombotic treatment increases the risk of an event fivefold[1]. Physically active individuals have a 25-30% lower risk of an ischemic event, and smoking cessation reduces the increased risk after 2-4 years[1]. Atherosclerosis is the most serious cause of an ischemic event, and its prevention consists in modifying lifestyle factors and controlling cardiovascular risk factors[1].