Stereotactic radiation improved key quality-of-life outcomes in patients with multiple brain metastases compared with whole brain radiation while avoiding the hippocampus (HA-WBRT).[1] A randomized phase III study demonstrated this benefit.[1] Stereotactic radiation is used for targeted irradiation of individual foci of brain metastases.[1] An alternative is whole brain radiation (WBRT) or partial radiation using IMRT or fractionated stereotactic radiotherapy (fSRT).[1] Brain metastases affect 20–40% of cancer patients, most often from the lungs (50%).[1] Due to the limited permeability of the blood-brain barrier, the role of systemic therapy is not clearly established.[1] Stereotactic radiosurgery can serve as a salvage treatment for limbic circuit involvement.[1]