Staphylococcus lugdunensis is a coagulase-negative staphylococci bacterium that is usually found on human skin but is increasingly causing serious infections, especially in premature infants.[1][3] A study documents a case of methicillin-resistant S. lugdunensis (MRSL) in an extremely premature neonate who was the first patient in an outbreak in a neonatal intensive care unit.[2] The bacterium was isolated from nasal ulcers of a newborn, and screening revealed its colonization in the nose, throat, and perineum.[2] Diagnosis was difficult because initial testing indicated sensitivity to methicillin, but further analysis by PCR detected the mecA gene responsible for resistance.[2] The strain belonging to sequence type 3 showed an unusual multidrug resistance profile due to SCCmec genetic elements and a plasmid with the potential to transfer resistance between other staphylococci.[2] The study points to the need for increased attention in the diagnosis of MRSL, as its detection can be difficult and its occurrence represents a serious threat in healthcare facilities.[1]