The researchers sequenced target genes in 493 pairs of tumor and normal tissues from 13 tumor types in domestic cats, focusing on orthologs of approximately 1,000 human oncogenes.[1][2] The most frequently mutated gene was TP53, with the most common copy number changes involving loss of PTEN or FAS or gain of MYC.[1] The study identified 31 driver genes, mutational signatures, viral sequences and germline variants predisposing to tumors.[1][5] In mammary carcinomas, common and aggressive in cats, they found seven driver genes, with FBXW7 being the most common in more than 50% of tumors and PIK3CA being the second in 47% of cases.[3][4] These changes resemble human oncogenes in breast, blood, bone, lung, skin, gastrointestinal, and CNS tumors.[3][4] The study confirms similarities with the human oncogenome and supports the cat as a model for comparative studies within the "One Medicine" approach.[1][2]