Bacteria supply a microtubule-binding protein to mammalian cells to promote their colonization[1][2][5]. The FhaB protein contains a C-terminal microtubule-binding domain (FhaB-CT) that translocates to the cytoplasm of the host cell[2]. This mechanism allows bacteria to efficiently colonize mammalian cells[1][2][5]. A study published in the journal Science (Volume 391, Issue 6787, Pages 825-830) identifies this process as key to bacterial pathogenicity[1][5]. A major finding is that FhaB-CT directly interacts with microtubules in the host cell, promoting bacterial adherence and spread[2].