This retrospective cohort study investigated the relationship between lactate dehydrogenase (LDH) enzyme level and anti-MDA5-positive dermatomyositis associated with interstitial lung disease (ILD).[1][6] The study included 168 patients with anti-MDA5-positive DM and found that LDH levels were significantly increased compared to the control group (p < 0.01).[6] Patients with the presence of anti-Ro-52 antibodies and elevated serum ferritin showed significantly higher LDH levels.[6] After treatment, LDH levels decreased in patients with improvement or stabilization of ILD, while they increased in patients with worsening ILD (p < 0.01).[6] Before treatment, LDH levels were significantly higher in the group of patients who died compared to the group who survived (p = 0.02).[6] The study concluded that LDH can serve as an effective indicator to evaluate changes in ILD in anti-MDA5-positive patients and that elevated LDH levels represent a key indicator of poor prognosis.[6]