An Incidental Finding Unraveled

Back to news list

Source: NEJM

Original: https://www.nejm.org/doi/full/10.1056/NEJMp2509681?af=R&rss=currentIssue...

Published: 2026-02-21T12:30:00Z

The patient had an incidental genomic finding that was unrelated to the original purpose of the test. This finding is referred to as an incidental finding (IF), i.e. an unexpected genomic result with potential medical significance. It occurs in genomic research in both healthy participants and patients and is sometimes called an unsolicited finding. The classification of IF is not always clear-cut, as knowledge about the genome continues to expand. When deciding on their submission, the analytical and clinical validity of the results, as well as their actionability – the availability of preventive or treatment options, are taken into account. Decisions are influenced by ethical principles such as respect for the person and beneficence. The European Society of Human Genetics (ESHG) recommends a cautious approach emphasizing proportionality and balance between health benefits and resources. They propose pilot projects to assess impact and feasibility.