Green nail syndrome (GNS) is characterized by green nail discoloration, paronychia, and onycholysis. The primary causative agent is usually the bacterium Pseudomonas aeruginosa, but coinfections with other pathogens are rare and present diagnostic and therapeutic challenges due to the lack of standard guidelines. The article describes a case report of GNS caused by co-infection with P. aeruginosa and the Burkholderia cepacia complex in a woman with a history of manicures and frequent exposure to water and cleaning agents at home. The diagnosis was confirmed by bacterial culture and antimicrobial susceptibility testing. Treatment included a combination of oral and topical levofloxacin, tailored according to bacterial susceptibility, resulting in complete cure of the infection. The case highlights the importance of microbiological identification in non-classic GNS and the success of targeted antibiotic regimens in complex co-infections.