The study analyzed 3,507,826 anonymized medical records of Mexican patients aged 6–100 years from Salud Digna clinics for the year 2023. Of these, 1,337,526 individuals (38.13%) were myopic, with an age-standardized prevalence of total myopia of 44.44%, low 43.31%, and high 1.12%. Myopia was defined as spherical equivalent refraction ≤ −0.50 D in the right eye, low as −6.0 D < SER ≤ −0.50 D, and high as SER ≤ −6.0 D. Low myopia was more common in men, high in women, with a peak at age 21–30 years (64.65% low, 1.75% high). The highest prevalence was in the central region (Mexico City, State of Mexico, Puebla, Tlaxcala). Astigmatism significantly increased the risk: mild 3-fold and 5-fold, moderate 8-fold and 33-fold, severe 11-fold and 100-fold for low or high myopia. Male sex, diabetes and high blood pressure reduced the risk of myopia. The authors emphasize the need for early detection due to the increasing prevalence of high myopia since childhood.