A study compared the effectiveness of aspirin and enoxaparin in preventing blood clots after major orthopedic surgery (hip and knee replacements, hip fracture surgery)[1][2]. The analysis included a total of 126,367 patients (43,441 with aspirin and 82,926 with enoxaparin) from different clinical trials[1]. In terms of preventing blood clots, enoxaparin was more effective - the incidence of deep vein thrombosis was significantly lower in the enoxaparin group and the incidence of pulmonary embolism was lower in this group[1]. In terms of safety, aspirin showed significant advantages - the risk of major bleeding was 40% lower and the risk of minor bleeding was 43% lower in the aspirin group compared to enoxaparin[1]. No significant differences were found between the two groups in wound complications, 90-day mortality, or hospital readmission rates[1]. The conclusion of the study suggests that aspirin is a safe alternative, especially for patients at higher risk of bleeding, although enoxaparin remains more effective in preventing blood clots[1].