Ralph Abraham, MD, the CDC's senior deputy director, has resigned effective immediately.[1][2][5] The CDC announced his resignation on Monday, citing unforeseen family obligations.[1][2][5] Abraham took office in January 2026 and served for only three months.[1][2] He was previously a congressman and surgeon general of Louisiana.[1][2] At CDC, he led work with career staff to strengthen national preparedness and improve emergency response.[2] Last week, CDC interim director Jim O'Neill stepped down, leaving Abraham to lead the agency on an interim basis until NIH's Jay Bhattacharya took over.[2] The CDC has not said who will replace Abraham.[1]