Drugmakers are making legal arguments against Donald Trump's drug pricing experiments in the Medicare system. These comments provide a blueprint for future legal challenges to efforts to lower drug prices in the US. Trump is urging companies like Eli Lilly, Sanofi, Regeneron, Merck & Co, Johnson & Johnson and AstraZeneca to provide Americans with lower drug prices. It wants people on low incomes to benefit more from the best price guarantee and for new medicines to be automatically offered at the lowest price. He gave the companies until September 29 to fulfill the requirements. Fourteen of the 17 largest drug companies have pledged to lower US drug prices in exchange for a three-year exemption from high tariffs. According to a study by the Rand Corp. as of 2024, prescription drug prices in the US are nearly three times higher than in other markets.