This is an editorial of concern regarding the article "Rescue of the Hippo coactivator YAP1 triggers DNA damage-induced apoptosis in hematological cancers". The article was published in Nature Medicine in June 2014 (doi: 10.1038/nm.3562). Statement published online 25 February 2026 (doi: 10.1038/s41591-026-04295-9). The editors express concern about this research. The study showed that low levels of YAP1 prevent nuclear ABL1-induced apoptosis in hematologic tumors such as lymphomas, leukemias, and multiple myeloma. YAP1 is regulated by the serine-threonine kinase STK4. Genetic inactivation of STK4 restores YAP1 levels and triggers cell death in vitro and in vivo. The results suggest a synthetically lethal strategy to target cancer cells with endogenous DNA damage and low levels of YAP1.[1][2]