The EVERDAC study was a multicenter, open-label, randomized, non-inferential trial in shock patients admitted to the intensive care unit within 24 hours. Patients were randomly assigned to early arterial catheterization within 4 hours (invasive strategy, 502 patients) or noninvasive arm cuff monitoring (504 patients), with the option of later catheterization if safety criteria were met. In the non-invasive group, 74 patients (14.7%) underwent catheterization, in the invasive group 493 (98.2%). The primary outcome was all-cause mortality within 28 days: 34.3% (173 patients) in the noninvasive group versus 36.9% (185 patients) in the invasive group (adjusted risk difference -3.2 percentage points, 95% CI -8.9 to 2.5; P=0.006 for noninference). Catheter-related bleeding occurred in 1.0% (5 patients) in the noninvasive group and in 8.2% (41 patients) in the invasive group. Management without prior arterial catheterization was noninferior to prior catheterization with regard to mortality within 28 days.[1][2]