Popular acid reflux medications, such as Prilosec, Nexium, and Protonix, can pose risks with long-term use. A new study found that prolonged use of these drugs disrupted iron and calcium levels in rats. These changes are associated with anemia and the risk of osteoporosis. The researchers observed shifts in the mineral balance in several organs of the rats. Experts agree that medications are effective against reflux. Long-term use without medical supervision can have unwanted consequences.