Artificial intelligence can transform the care of people with rare diseases if it is organized around the patient journey. Authors Tudor Groza, Gareth Baynam and Saumya Shekhar Jamuar outline the patient-doctor-AI triad. This triad includes early detection, diagnosis, clinical trials, and individualized therapies. The article discusses how artificial intelligence can transform rare disease care. It focuses on organization according to the patient's journey. The perspective highlights the role of AI in the entire process from detection to therapy.