The editorial focuses on advances in the nutritional management of patients with renal failure, a global health problem.[2] Nutritional support includes the traditional restriction of protein and salt, but more and more attention is paid to the balance of trace elements and micronutrients.[2] The topic explores the optimal nutritional composition tailored to these patients.[2] Special emphasis is placed on the unique balance of amino acids and trace elements essential for their health.[2] Includes basic and clinical research on specific nutrients for patients with renal failure.[2] The prevalence of sarcopenia and frailty in these patients with nutritional implications is also addressed.[2] Nutritional management is characterized by complexities and uncertainties, and optimization of strategies is crucial for comprehensive care.[2][8]