A single dose of amphetamine-dextroamphetamine (Adderall) caused acute cardiovascular effects in healthy young people who did not use it regularly, according to a small controlled study published on MedPage Today. Resting systolic blood pressure increased significantly. The study found these changes shortly after the drug was administered. Another study in children with ADHD showed that the short-term cardiovascular effects of Adderall at doses up to 15 mg/day were modest and clinically insignificant, with no significant changes in pulse, diastolic, or systolic blood pressure.[1] Long-term use of stimulants like Adderall increases the risk of cardiomyopathy in young adults—by 17% after one year and 57% after eight years compared to non-users.[2] Cardiomyopathy weakens the heart muscle and can lead to fatigue and limitation of normal activities. The study followed 12,759 pairs of patients for at least 10 years.[2]