A 62-year-old postmenopausal woman with a history of hemorrhagic stroke 7 years ago, hemiplegia, 3-month dysphagia, and slurred speech was admitted for postmenopausal bleeding. Diagnostic curettage revealed FIGO stage I endometrioid adenocarcinoma of the endometrium. She underwent laparoscopic hysterectomy, bilateral salpingo-oophorectomy and sentinel lymph node mapping. After surgery, she was transferred to the ICU with mechanical ventilation; extubation failed on POD 2, tracheostomy was performed on POD 4 due to previous history. Enteral feeding via a nasogastric tube was discontinued due to intolerance, on POD 8 she was weaned from ventilation and transferred to the ward. The multidisciplinary team ensured airway patency, nutrition, skin protection and pressure ulcer prevention. POD 17 she was discharged home with a tracheostomy tube, removed a week later, and was tolerating mashed potatoes. The case highlights the importance of MDT collaboration in the perioperative care of patients with endometrial cancer and stroke sequelae.