The new issue of JAMA focuses on three main topics. The first is a comparison of individual risk-based breast cancer screening with annual screening, with the J WISDOM study examining the health risks associated with both approaches. The second topic is precision immunotherapy in sepsis, where the ImmunoSep randomized clinical trial evaluates its impact on improving treatment outcomes. The third topic covers an overview of IgA nephropathy in adults, including a podcast with CME credits. An editorial on breast cancer risk screening and precision sepsis therapy is also included.