A 58-year-old woman was diagnosed with prosthetic mitral valve endocarditis due to Candida albicans one year after valve replacement surgery for severe regurgitation. The diagnosis was confirmed by recurrent fever, positive blood cultures and echocardiographic vegetations. The isolate was sensitive to amphotericin B, azoles and echinocandins. The patient met the criteria for surgical reoperation, but refused it. She received liposomal amphotericin B combined with high-dose caspofungin as rescue therapy, which resulted in resolution of symptoms and regression of vegetations on follow-up imaging. The patient was discharged for life-long suppressive antifungal treatment according to the sensitivity profile.