The study examined the effect of the Mediterranean diet on symptom severity in patients with Sjogren's syndrome using the OSDI (Ocular Surface Disease Index) and ESSPRI (Eular Sjogren's Syndrome Patient-Reported Index) scores. It was a cross-sectional observational study with 75 patients with an average age of 50.1 ± 13.3 years, of which 88% were women. Median scores were 5.0 for ESSPRI (IQR 3.0–6.7), 25.0 for OSDI (IQR 10.4–40.6) and 8.0 for MEDAS (IQR 4.5–11.0), where MEDAS assesses adherence to a Mediterranean diet. Spearman's correlation analysis showed a significant negative correlation between MEDAS and OSDI (ρ = -0.78, p < 0.001). No covariate was statistically significant in the ESSPRI model, while treatment showed a positive correlation with OSDI (β = +6.44, 95% CI 0.84 to 12.03; p = 0.025). The Mediterranean diet can serve as a complementary strategy to conventional treatment.