After President Trump's announcement at a White House briefing last fall, emergency department orders for acetaminophen (Tylenol) for pregnant women dropped and outpatient prescriptions for leucovorin (Wellcovorin) increased. Trump and Health Secretary Robert F. Kennedy Jr. mentioned data suggesting that taking Tylenol during pregnancy may increase the risk of autism in the child and that leucovorin may improve speech in some patients with autism. These figures have been circulating for more than a decade, but have not been unequivocally confirmed. One study reported a 5 percent increase in the risk of autism, a meta-analysis of other studies reported a 20 percent increase. A review of 46 studies published last month in the journal Environmental Health, involving researchers from Harvard and the Icahn School of Medicine at Mount Sinai, concluded that pregnant women should limit acetaminophen to protect the neurodevelopment of the offspring. However, some autism researchers have criticized the review's methodology. Scientists debate whether Tylenol directly causes autism, or whether it is more commonly used by women with conditions such as infections or migraines that may be associated with autism.[1][2]