A study published in the journal eClinicalMedicine analyzed data from 6,527 pregnant women from 18 countries between 2020 and 2022.[1] Infection with COVID-19 during pregnancy was associated with a 45% increase in the risk of preeclampsia, with the risk rising to 78% in unvaccinated women.[1][2] Vaccination against COVID-19 with a booster dose reduced the overall probability of preeclampsia by 33%.[1][2] In women with pre-existing conditions such as diabetes, hypertension or thyroid disorders, the booster dose reduced the risk of preeclampsia by 42%.[2] Vaccinated women had a 33% lower risk of preterm birth, a 32% lower risk of maternal morbidity and mortality, and a 29% lower risk of severe perinatal morbidity and mortality.[2] These findings suggest that vaccination may affect the immune and vascular mechanisms associated with preeclampsia even in the absence of COVID-19 infection.[1][2] The TTHealthWatch podcast from Texas Tech and Johns Hopkins Medicine covers these topics along with HPV testing from menstrual blood.