GLP-1 Drugs and Bone Injury; 'Fire-Breathing' Teen Trend; Saunas' Health Benefits?

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Source: MedPage Today

Original: https://www.medpagetoday.com/endocrinology/obesity/120213...

Published: Mon, 09 Mar 2026 09:36:07 -0400

A retrospective study suggests that GLP-1 receptor agonists may increase the risk of bone and tendon injuries, along with diseases such as osteoporosis and gout[1]. These drugs are associated with a higher incidence of fractures, although other studies show mixed results, for example an adjusted hazard ratio of 0.89 (95% CI 0.71–1.13) when compared with non-diabetics[1]. A meta-analysis of 16 studies with 11,206 participants showed no overall change in bone fracture risk (MH OR 1.05, 95% CI 0.59–1.87)[1]. There was a significant increase in risk with liraglutide (MH OR 2.09, 95% CI 1.03–4.21)[1]. The article also mentions the teenage trend of "fire breathing" and the health benefits of the sauna, but does not detail them[1]. Some sources suggest that GLP-1 agonists may not increase fracture risk compared to untreated patients (HR 0.99, 95% CI 0.82–1.19)[1].