The article describes the case report of a 61-year-old man whose infection with the varicella-zoster virus (VZV) led to serious complications. Clinical signs began with Hutchinson's sign, characterized by VZV lesions on the tip, dorsum, and root of the nose. This symptom is a strong predictor of eye complications in herpes zoster ophthalmicus (HZO). Symptoms progressed to HZO, subsequently to multiple bilateral cranial neuropathies and acute cerebral infarction. Bilateral ophthalmoplegia also developed. The presence of Hutchinson's sign is strongly correlated with ocular complications of HZO. Bilateral involvement of the cranial nerves and cerebral infarcts indicate spread of the virus in the central nervous system.