Hodgkin's lymphoma (HL) is a type of cancer of the lymphatic system that is diagnosed by the presence of Reed-Sternberg (RS) cells surrounded by immune cells[3]. The researchers investigated the expression of two proteins – CD161 and lectin-like transcript 1 (LLT1) – in RS cells because these proteins modulate the function of natural killer and T cells in cancer[3]. The study analyzed tissue samples from patients in northern Jordan and 60 control samples from healthy lymph nodes and tonsils using immunohistochemistry[3]. It was the first study that detected the expression of CD161 in RS cells at the protein level[3]. Statistical analyzes showed no significant association between LLT1 or CD161 expression in RS cells and Epstein-Barr virus type, stage, or status[3]. The researchers concluded that these findings provide the first characterization of LLT1 and CD161 expression in RS cells and suggest their potential use as targets in immunotherapeutic approaches for the treatment of Hodgkin's lymphoma[3].