Risk factors for the development of cirrhosis within 1-year in non-cirrhotic patients with HBV- related acute-on-chronic liver failure

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Source: Frontiers Medicine

Original: https://www.frontiersin.org/articles/10.3389/fmed.2026.1743728...

Published: 2026-03-10T00:00:00Z

The study examined risk factors for developing liver cirrhosis within one year in patients with hepatitis B-related acute liver failure who did not have cirrhosis at baseline. Of the 109 enrolled patients, cirrhosis developed in 21.1% of them during the one-year follow-up. Research identified three main predictors of cirrhosis progression: failure to correct total bilirubin levels within 28 days, failure to normalize international normalized ratio (INR) within 28 days, and lower platelet count at baseline. Normalization of INR showed the strongest predictive accuracy for the development of cirrhosis. Based on these factors, they created an algorithm that divided patients into three risk groups with an incidence of cirrhosis of 5.4% (low risk), 29.4% (medium risk) and 77.8% (high risk).