The article proposes the application of Marie Kondo's method to the design of clinical trial protocols with an emphasis on subtractive changes, i.e. removing unnecessary elements. Author Rachel Bender Ignacio argues that clinical trial protocols are often cluttered with unnecessary procedures, increasing costs and complicating research. He points to the principle of “does it glow with joy?” that should be applied to every element of the protocol, leaving only those essential to scientific integrity and patient safety. Subtractive changes could reduce the administrative burden and improve the efficiency of trials without losing data quality. Examples include eliminating unnecessary measurements or procedures that do not contribute to the main objectives. This approach is inspired by Kondo's cleaning philosophy, adapted for clinical research.