A 68-year-old woman was admitted to the hospital due to impaired consciousness and fever. Hepatic and renal dysfunctions occurred, blood glucose level was 278 mg/dL. Prothrombin time – international normalized ratio reached 2.82 (norm 0.85–1.15), activated partial thromboplastin time 54.6 s (norm 24.3–36.0 s), fibrinogen 130.1 mg/dL (norm 150–400 mg/dL), and D-dimer 195.4 µg/mL (norm <1.0 µg/mL). There was macroscopic hematuria in the urine and a bleeding tendency, indicating disseminated intravascular coagulation. Based on the severe course of sepsis and hemolysis, Clostridium perfringens bacteremia was suspected. Giemsa staining of blood smear showed bacilli phagocytosed by leukocytes. Massive intravascular hemolysis occurs in 7–15% of cases of C. perfringens bacteremia, with a mortality of 70–90% and a mean time to death of 9.7 hours.[1]