Soft tick relapsing fever (STRF) is a rare infection caused by spirochetes of the genus Borrelia, transmitted by soft ticks of the genus Ornithodoros, such as O. turicata, O. hermsii or O. parkeri.[1][5] In the US, it is often found after exposure in rustic cabins, camping, or caves, especially in the south-central part of the country.[1][5] The clinical presentation includes a high fever lasting approximately 3 days, relapsing every 7–10 days up to two or more times if untreated.[1] Among 207 patients with clinical data, 97% had fever, with a median of two episodes (range, 1–9); other symptoms were headache (63%), muscle aches (59%), chills (54%), and nausea or vomiting (45%).[1] Of the 211 patients, 55% were hospitalized, including 44% of children under 12 and 67% of adults over 65; no deaths were reported.[1] The incubation period after a tick bite is on average 1 week.[2][6] Antibiotic treatment is highly effective, relapses occur due to the bacteria's ability to escape the host's immune system.[1][7]