Coenzyme A is a molecule derived from vitamin B5 and is vital for metabolism throughout the body. Most of the coenzyme A is found in the mitochondria, which are the powerhouses of the cell. Until now, it was not clear how coenzyme A gets into these mitochondria. Researchers at Yale University have identified a transport system that moves coenzyme A into mitochondria. The discovery solved a long-standing biological puzzle. The research could help to better understand diseases associated with metabolic dysfunction and mitochondrial problems.