Scientists led by Matthias-Claudio Loretto performed a lifetime behavioral screen in vertebrates that revealed the architecture of aging.[1] The study was published in the journal Science, Volume 391, Issue 6790, on March 12, 2026.[1] Research has followed the behavior of animals throughout their lives to identify patterns associated with aging.[1] The main findings show a specific pattern of behavioral changes in vertebrates with age.[1] This architecture of aging includes measurable declines in cognitive and physical abilities.[1] The study highlights universal principles of aging across vertebrate species.[1]