A study of 5,981 US adults from 2017 to 2020 found that women with multiple cardiometabolic risk factors faced a significantly higher risk of clinically significant liver fibrosis compared to men[1]. Cardiometabolic risk factors include being overweight or obese, elevated glucose levels, high blood pressure, elevated triglycerides, and low HDL cholesterol levels[1]. When women had two or more of these factors, the risk of liver fibrosis was more than three times higher than in men with the same number of factors[1]. Central fat storage and glucose tolerance disorders were particularly dangerous for women[1]. Researchers emphasize the need for sex-specific approaches in the screening and prevention of liver fibrosis in women with these risk factors[1].