The study examined how well genetic risk scores for body mass index and blood pressure, which were developed based on European populations, performed in Brazilian people of mixed ancestry. The researchers tested 33 scores for body mass index, 36 for systolic blood pressure, and 33 for diastolic blood pressure in 4,758 participants from two Brazilian regions. Most scores for body mass index were validated (96.7% in São Paulo and 90.9% in Northern Minas Gerais), while blood pressure scores showed a lower validation rate (38.9 to 69.7%). However, all validated scores showed lower effects in Brazilian participants compared to European data. Score effects were larger for Brazilian whites than for non-whites (+0.60 kg/m² per standard deviation). The study concluded that European genetic scores are not directly transferable to the Brazilian population without prior empirical validation and that new scores need to be developed specifically for Brazilian genomic data.