The study investigated the efficacy of percutaneous electrolysis (PE) in subacute and early chronic medial gastrocnemius muscle injuries that cause persistent pain, functional limitations, and delayed return to activity. Participants were randomly divided into three groups: high-intensity PE (n=23), low-intensity PE (n=23), and a sham control group (n=25). They completed three sessions once a week for three weeks. Pain during walking and contraction, fatigue, kinesiophobia and ankle range of motion were assessed at the beginning and after the intervention. High-intensity PE significantly reduced walking and contraction pain compared to the sham group (p < 0.05). Low-intensity PE significantly reduced fatigue compared to the sham group (p = 0.024). No significant differences were found in kinesiophobia or range of motion between groups, although there was improvement in several outcomes within the PE treatment groups (all p < 0.05). The conclusion of the study states that PE effectively reduces pain during walking and contraction as well as fatigue compared to sham (NCT06713200).