Subthreshold micropulse laser (SML) is an effective and safe treatment method for chronic central serous chorioretinopathy (cCSC), which can lead to permanent visual impairment. A systematic review and meta-analysis of 21 studies with a total of 939 eyes demonstrated that SML significantly improved the visual acuity of patients with cCSC. Treatment also significantly reduced central macular thickness, choroidal thickness, and central retinal thickness. Efficiency was consistent regardless of the laser wavelength used (527, 532, 577 or 810 nanometers). Although the improvement in subretinal fluid height was not statistically significant, most studies indicated a positive trend. SML has demonstrated a high safety profile in the treatment of cCSC and represents a safe and effective treatment option for this disease.