Major changes in cardiovascular guidelines suggest that adults in their 30s be assessed for cholesterol risk. Cardiology groups recommend considering statin therapy to prevent heart attack and stroke. These changes emphasize early prevention in primary care. In the Czech Republic, the National Cardiovascular Plan for 2025–2035 strengthens interdisciplinary cooperation and data availability. New preventive screenings include determination of NT-proBNP in persons older than 50 years with at least two risk factors for heart failure, or in persons older than 60 years with one factor. The plan supports delegated prescribing by general practitioners and timely echocardiographic examinations within four weeks. In the EU, cardiovascular diseases cause 1.7 million deaths per year and an economic burden of 282 billion euros. Implementation includes educational activities, digitization and improving the availability of innovative treatment.[1][3][6]